Weekly outline

  • Biochemistry

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    Understanding  metabolic  biochemistry  is  essential  for  medical  students  because  it  provides  the  foundation  for understanding how cells obtain and use energy, and build necessary components, and how imbalances in these processes can lead to diseases such as diabetes, obesity, and metabolic syndrome.

    This knowledge will be crucial as you advance your medical education and encounter clinical scenarios involving metabolic disorders, drug metabolism, and nutritional biochemistry.

  • ‎Author’s presentation ‎

    Dr. FATMI Ahlam

    Institute: Sciences Univ- M’sila‎

    Department: medicine annex

    Contact: fatmi.ahlam@univ-msila.dz

    Availability: ‎Teachers' room: Sunday, Monday, and Tuesday from 10:00 a.m. to 12:00 p.m.‎

    By email: I undertake to respond by email within 24 hours following receipt of the message, except in the event of unforeseen circumstances.


  • Learning Objectives

    It is a complex performance, which you will gradually build by mastering knowledge, implementing know-how, and doing it with professional know-how. Then at the end of this course, students must master the theoretical concepts and acquire basic knowledge in biochemistry more particularly:

     

      •    In terms of knowledge, I will teach you the basic notions of metabolic biochemistry and the different metabolic pathways of food biomolecules (carbohydrates, lipids, and proteins).
      •    In terms of know-how: extract the energy balance of each metabolic pathway. Compare the metabolic pathways at the reaction and enzymatic levels.
      •    In terms of soft skills: distinguish between metabolic pathways. Moreover, it evaluates the disorders involved in metabolic pathology.

     



  • Prerequisites

    The prerequisites for this subject consist of having sufficient basic knowledge acquired in the subject of general chemistry structural biochemistry taught in the 1st semester.

    That is to say, students know the structures and spatial conformations of carbohydrates, and proteins as well as the structure of simple and complex lipids and develop the physicochemical properties of these molecules as well as their study methods. The chemical structure and main properties of macromolecules and molecules of the cell.

  • Course plan

    I. The first chapter studies carbohydrates:

        1.  Gglycolysis
        2.  Krebs cycle,
        3. Gluconeogenesis
        4.  The pentose phosphatase pathway
        5. Glucgene metabolism

     

    II.  The second chapter of lipids :

        1.  β-oxydation and synthesis of fatty acids and their regulation
        2. Metabolism of: 
              1. Ketone bodies
              2. Triglycerides, 
              3. Cholesterol
              4. Phospholipids
              5.  Lipoproteins.

     

    III.  The third chapter the metabolism of amino acids:

        1.  Decarboxylation
        2. Transamination
        3. Deamination
        4. Ammonia metabolism “ urogenesis and ammoniogenesis”


  • The glycolysis: the pathway of EMBED- MEYEROFF-PARNAS

    This week


    Objectives

    • know the products and enzymes implicated in every step of glycolysis.
    • would calculate the energetic balance of glycolysis.

  • The Krebs Cycle “Citric Acid Cycle”


    Objectives

    At the end of their training, the student must master 

    • know the products and enzymes implicated in every step in the Krebs Cycle.
    • Understand what happens at each stage to the products.
    • would calculate the energetic balance of the Krebs Cycle.

  • Final Exam

    The final evaluation is done through a final exam on the table which covers everything ‎you ‎have seen in this course during the semester, which counts for 100% of ‎the ‎final mark.

  • Support Ressources

    1. Cathérine Baratti-Elbaz et Pierre Le Maréchal, 2015- Biochimie. Ed. Dunod, Paris, 160p.
    2. Norbert Latruffe, Françoise Bleicher-Bardelett, Bertrand DucloS et Joseph Vamecq, 2014- Biochimie. Ed. Dunod, Paris.
    3. Kevin Ahern., Indira Rajagopal. Biochemistry Free and Easy. 2012, 2013. Version 2.0
    4. Peter K. Robinson. Enzymes: principles and biotechnological applications. 2015. Essays in Biochemistry 59:1-41
    5. Sophie Seronie-Vivien. 2015. Biochimie et Biologie moléculaire. Edition: Collection PACES. Editor: Ellipses Marketting.
    6.  Georges Hennen, 2006. Biochimie Approche bioénergétique et médicale Version 4.0. Ed. Dunod, Paris.
    7.  David L. Nelson et Michael M. Cox, 2017. Lehninger Principles of Biochemistry. Ed. Seventh